Brief Biography

Dr. Anne-Marie Guerguerian received her MD in 1993 from the Université de Montréal and followed up with a specialization in Paediatrics. In 1998, she undertook a Post-doctoral Fellowship in the Department of Critical Care Medicine at The Hospital for Sick Children (SickKids). She completed attended Johns Hopkins University in 2002, completing another Post-doctoral Fellowship in the Department of Anesthesiology & Critical Care Medicine at the Bloomberg School of Public Health, Graduate Training Program in Clinical Investigation. Dr. Guerguerian is a member of the Royal College of Physicians and Surgeons of Canada, has certification with Pediatrics and Critical Care Medicine, the American Board of Pediatrics and Pediatrics & Pediatric Critical Care Sub-Specialist.

In 2002 Dr. Guerguerian served as an instructor in Pediatric Critical Care Medicine in the Department of Anesthesiology & Critical Care Medicine at Johns Hopkins University and in 2003 became an Assistant Professor. She joined SickKids in 2004.

Research Interests

• Brain Injury
• Cerebral Metabolism in Critically Illness
• Clinical Trials and Research Design Methodology

Research Activities

My program of research aims to bridge the gap that lies between neuroprotective research in animal models and clinical trials in the developing brain of critically ill children. Particular research projects involve the development and implementation of methods that allow the measurement of cerebral physiologic and neurochemical changes occurring after injury. This research will allow us to better understand how therapies can be adapted to target the developing brain to improve early and longer-term outcomes after acquired brain injury.

External Funding

2007- 2009 Ontario Neurotrauma Foundation Grant

Achievements

• 2000 Young Investigator Award in Neurosciences, 3rd World Congress on Pediatric Intensive Care
• 2000 Research Training Award, Université de Montréal
• 2001 Chest Foundation Trainee Award in Clinical Research in Critical Care
• 2001 Senior Research Fellowship Phases I, Canadian Institutes of Health Research
• 2003 Young Investigator Award, 4th World Congress on Pediatric Intensive Care
• 2003 Samuel Heulett Award for Brain Injury Research
• 2005 Senior Research Fellowship Phases II, Canadian Institutes of Health Research
• 2008 Trillium Gift of Life Network Donation Champion Award

Publications

Salorio CF, Slomine BS, Guerguerian AM, Christensen JR, White J, Natale JN, Shaffner DH, Grados M, Vasa RA, Gerring JP. Intensive care unit variables and outcome after pediatric traumatic brain injury. Pediatric Critical Care Medicine. January 2008, 9(1):47-53. (CME special article).

Morrison W, Hunt E, Guerguerian AM. Research Design and Statistical Analysis. Rogers Textbook of Pediatric Intensive Care, Fourth Edition. 2007

Natale JE, Guerguerian AM, Joseph JG, McCarter R, Shao S, Slomine B, Christensen J, Johnston MV, Shaffner DH. Pilot study to determine the hemodynamic safety and feasibility of magnesium sulfate infusion in children with severe traumatic brain injury. Pediatr Crit Care Med. 2007 Jan;8(1):1-9.

Natale JE, Joseph JG, Pretzlaff RK, Silber TJ, Guerguerian AM. Clinical trials in pediatric traumatic brain injury: unique challenges and potential responses. Developmental Neurology Special Edition on Pediatric Traumatic Brain Injury. Dev Neurosci. 2006;28(4-5):276-90.

Agnew DM, Koehler RC, Guerguerian AM, Shaffner DH, Traystman RJ, Martin LJ, Ichord RN. Hypothermia for 24 hours after asphyxic cardiac arrest in piglets provides striatal neuroprotection that is sustained 10 days after rewarming. Pediatric Research. August 2003; 54(2):253-262.

Guerguerian AM, Brambrink AM, Traystman RJ, Huganir RL, Martin LJ. Altered expression and phosphorylation of N-methyl-D-aspartate receptors in piglet striatum after hypoxia-ischemia. Brain Research Molecular Brain Research. July 15 2002;104(1):66-80.

Guerguerian AM, Gauthier M, Lebel MH, Farrell CA, Lacroix J. Ribavirin in ventilated respiratory syncytial virus bronchiolitis. a randomized, placebo-controlled trial. American Journal Respiratory & Critical Care Medicine. 1999;160(3):829-834.