Jamie Hutchison , MD, FRCPC
The Hospital for Sick Children
Research Director
Critical Care Medicine
Research Institute
Senior Scientist
Neurosciences & Mental Health
University of Toronto
Associate Professor
Departments of Critical Care and Paediatrics
Chair Positions
Canadian Critical Care Trials Group
Co-Chair of the Paediatric Interest Group
Phone: 416-813-4918
Fax: 416-813-7299
e-mail: jamie.hutchison@sickkids.ca
Brief Biography
Dr. Hutchison is a staff physician and scientist with a focus on neurocritical care and brain injury.
Research Interests
Laboratory research
- Role of leukocyte adhesion to endothelial cells in the cerebral microcirculation following global cerebral ischemia.
- Role of inhibitor of apoptosis proteins following brain injury.
- Mechanisms of hypothermia therapy following brain injury.
Clinical research
Epidemiology, prognosis and therapeutic trials in brain injury.
External Funding
- Canadian Institutes of Health Research
- National Institutes of Health
- Heart and Stroke Foundation of Ontario
- Ontario Neurotrauma Foundation
- SickKids Foundation
- Physician Services Incorporated
Publications
Hutchison JS, Ward RE, Lacroix J, Hébert PC, Barnes MA, Bohn DJ, Dirks PB, Ferguson D, Gottesman R, Joffe A, Kirpalani HM, Meyer PG, Morris KP, Moher D, Singh RN, Skippen PW for the Hypothermia Pediatric Head Injury Trial investigators and the Canadian Critical Care Trials Group. Hypothermia therapy following traumatic brain injury in children. N Engl J Med 2008;358:28-37.
Hutchison JS, Doherty DR, Orlowski J, Kissoon N. Hypothermia therapy for cardiac arrest in pediatric patients. Pediatr Clin N Am 2008;55:529-544.
Hare GMT, Mazer CD, Hutchison JS, McLaren AT, Liu E, Rassouli A, Ai J, Shaye R, Lockwood JA, Hawkins CE, Sikich N, To K, Baker AJ. Severe hemodilutional anemia increases cerebral tissue injury following acute neurotrauma. J Appl Physiology 2007; 103:1021-1029.
Lacroix J, Hébert PC, Hutchison JS, Hume HA, Tucci M, Ducruet T, Gauvin F, Collet J-P, Toledano BJ, Robillard P, Joffe A, Biarent D, Meert K, Peters MJ, on behalf of the TRIPICU investigators, for the Canadian Critical Care Trials Group and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Transfusion requirements in pediatric intensive care units study — a multicenter randomized controlled noninferiority clinical trial. New Engl J Med 2007; 356:1609-1619.
Mikrogianakis A, Shaye RE, Griffin P, Gendron NH, Gaboury I, MacKenzie AE, Hutchison JS. The effect of hypoxia on inhibitor of apoptosis protein (IAP) expression following traumatic brain injury in the mouse. J Neurotrauma 2007;24:338-353.
Haqqani A, Hutchison J, Ward R, Stanimirovic D. Protein biomarkers in serum of pediatric patients with severe traumatic brain injury identified by ICAT-LCMS/MS. J Neurotrauma 2007;24:54-74.
Hutchison J, Ward R, Lacroix J, Hébert P, Skippen P, Barnes M, Meyer P, Morris K, Kirpalani H, Singh R, Dirks P, Bohn D, Moher D, for the HyP-HIT investigators and the Canadian Critical Care Trials Group. Hypothermia pediatric head injury trial (HyP-HIT): the value of a pre-trial clinical evaluation phase. Dev Neurosci 2006;28 (4-5):291-301.
McIntyre LA, Fergusson DA, Hébert PC, Moher D, Hutchison JS. Prolonged therapeutic hypothermia after traumatic brain injury in adults: a systematic review. JAMA 2003; 289:2992-9.