Brief Biography

Jill Hamilton received her medical degree at The University of Ottawa, Ontario and Paediatric specialty degree at The University of Toronto. She trained in Paediatric Endocrinology at The Hospital for Sick Children, Toronto.
She is currently Staff Physician in the Division of Endocrinology, Department of Paediatrics and Associate Professor , University of Toronto and Associate Scientist at the Research Institute at The Hospital for Sick Children.

Clinical Care Activities 

• comprehensive tertiary care of children and teens with complex obesity, including bariatric surgery patients 
• care of children with endocrine and metabolic disorders, with an interest in hypothalamic obesity, polycystic ovarian syndrome, Turner syndrome and thyroid cancer

Research Interests

• obesity
• insulin resistance/beta cell secretion and type 2 diabetes
• Turner Syndrome
• thyroid cancer

Research Activities

My research interests include the clinical and biochemical manifestations of insulin resistance and pancreatic beta cell function in the pediatric age group. Recent studies include: (i) risk for diabetes and metabolic syndrome and pathophysiologic mechanisms related to the development of hypothalamic obesity in children treated for craniopharyngioma; (ii) early life risk factors for the development of obesity and diabetes in infants born to women with gestational diabetes; (iii) incidence and clinical presentation of type 2 diabetes in Canadian children (iv) risk for insulin resistance and cardiovascular disease in girls with Turner Syndrome;  (iv) role of ectopic fat deposition and metabolic consequences in obese children and adolescents.  I have a secondary interest in pediatric thyroid cancer and have studies evaluating  (i) longitudinal followup; (ii) quality of life; (iii) cell cycle markers in differentiates thyroid cancer; (iv) ultrasound sensitivity in detecting malignant thyroid nodules.

Future Research Interests

Randomized controlled trial of motivational interviewing for weight loss in obese adolescents.

Publications

Amed S, Dean H, Panagiotopoulos C, Sellers E, Hadjiyannakis S, Laubscher T, Dannenbaum D, Shah B, Booth G, Hamilton J.  National surveillance for non-type 1 diabetes mellitus in Canadian children: type 2 diabetes, medication induced diabetes, and monogenic diabetes.  Diabetes Care 2010 Jan 12. [Epub ahead of print].

Rakhshani N, Jeffery A, Schulte F, Barrera M, Atenafu E, Hamilton J.  Evaluation of a comprehensive care clinic model for children with brain tumour and risk for hypothalamic obesity  Obesity 2010 Jan 7 epub ahead of print

Retnakaran R, Qi Y, Goran M, Hamilton J.  Evaluation of proposed oral disposition index measures in relation to the actual disposition index. Diabetic Medicine 2009 Dec;26(12):1198-203.

Hamilton J, Odrobina E, Hanley A, Zinman B, Retnakaran R.  Effect of maternal insulin sensitivity during pregnancy on infant weight gain and adiposity at 12 months of age. Obesity 2009 epub Aug 6

Simoneau-Roy J, O’Gorman C, Pencharz P, Adeli K, Daneman D, Hamilton J.  Insulin secretion and sensitivity in children and adolescents with hypothalamic obesity following treatment for craniopharyngioma.  Clin Endocrinol 2009 epub May 25.

Buccino J, Daneman D, Hamilton J: Nutritional education for children with type 2 diabetes mellitus (T2DM).  Canadian Journal of Dietetic Practice and Research 2008; 69(4) 192-197

Retnakaran R, Shen S, Hanley T, Vuksan V, Hamilton J, Zinman B. Hyperbolic relationship between insulin secretion and insulin sensitivity on oral glucose tolerance test. Obesity 2008 Aug;16(8):1901-7.

Rachmiel M, Kives S, Atenafu E, Hamilton J: Primary amenorrhea as a manifestation of polycystic ovarian syndrome in adolescents: a unique subgroup?  Archives Pediatr and Adol Medicine 2008;162 521-525

Wells GD, Noseworthy MD, Hamilton J, Tein I: Skeletal muscle dysfunction in obesity: new ideas and concepts.  Can Journal of Neurol. Sci: 2008: 35:31-40

Segal P, Hamilton J, Sermer M, Connelly P, Hanley A, Zinman B, Retnakaran R: Maternal obesity and familial history of diabetes have opposing effects on infant birthweight in women with mild glucose intolerance in pregnancy. Journal of Maternal-Fetal and Neonatal Medicine. Matern Fetal Neonatal Med. 2008 Jan; 21(1):73-9.

Ong G, Hamilton J, Sermer M, Connelly PW, Maguire G, Zinman B, Hanley AJ, Retnakaran R: Maternal serum adiponectin and infant birthweight: the role of adiponectin isoform distribution.  Clinical Endocrinology  2007: 68: pp 236-243.

Zdravkovic V, Hamilton J, Daneman D, Cummings E: Pioglitazone as adjunctive therapy in adolescents with type 1 diabetes.  Journal of Pediatrics 2006: 49(6): pp 845-849.

Rachmiel M, Charron M, Gupta A, Hamilton J, Wherrett D, Forte V, Daneman D: Evidence-based review of treatment and follow-up of pediatric patients with differentiated thyroid cancer.  Journal of Pediatric Endocrinology Metabolism 2006: 19(12): pp 1377-94.

Ahmet A, Blaser S, Stephens D, Guger S, Rutka JT, Hamilton J: Risk factors for weight gain in children treated for craniopharyngioma.  Journal of Pediatric Endocrinology and Metabolism 2006: 19(2): pp 121-128.