For more information, visit:

• Mital Lab
• Transatlantic Alliance
• Heart Centre Biobank

Brief Biography

Dr. Seema Mital received a bachelor’s degree in medicine and surgery in 1989 from Bombay University. She completed her pediatric residency at Wayne State University in 1996 and a fellowship in pediatric cardiology in 1999 from Columbia University in New York.  Dr. Mital served as an assistant professor at Columbia University, Morgan-Stanley Children’s Hospital of New York, until 2007 when she joined SickKids as staff cardiologist.  

Clinical Care Activities

• Paediatric heart failure and heart transplantation

Research Interests

• Genome-wide approach to study the genetic and environmental basis of heart disease in children and adults:
• Genetic determinants of outcomes in congenital heart disease and cardiomyopathy
• Pharmacogenetic and personalized medicine approaches in children with heart disease
• Stem cell regulation in cardiac malformations and use of reprogrammed human induced pluripotent stem cells for disease modeling and drug discovery
• Molecular basis of right ventricular adaptation and failure

Research Activities

• Principal Investigator, SickKids Heart Centre Biobank, an Ontario province-wide heart centre biobank to study the genetic and environmental basis of heart disease in children and adults
• Principal Investigator, SickKids Transplant Centre Biobank, to study genomics in transplant patients
• Multicenter study of genetic determinants of outcomes in heart disease through the Pediatric Heart Network
• Cardiac differentiation of pluripotent stem cells for disease modeling and drug discovery
• Cardiac biomarker discovery using stem cell approaches in heart disease (MRI-GL2)
• International Network for training and education in genomics of heart disease (MRI-ISOP)

External Funding

Principal Investigator, Heart and Stroke Foundation of Ontario, Biologic determinants of right ventricular remodeling in tetralogy of Fallot

Principal Investigator, Ontario Ministry of Research and Innovation International Strategic Opportunities Program, GenomeHeart: An International Network to Study Cardiac Malformations

Co-Investigator, Ontario Research Fund - Global Leadership Round in Genomics & Life Sciences Competition (GL2 Competition), Cardiovascular Biomarker Discovery in Disease and Development through Predictive Precision Proteomics (CBD3P3)

Co-Investigator, Canadian Institutes for Health Research, Clinical Assessment of Thrombosis in Children and Heart surgery: The CATCH study

Principal Investigator, NIH/NLHBI Pediatric Heart Network (UO1 HL068288) ancillary study: Genetic polymorphisms in pediatric cardiomyopathy

Site PI: NIH/NLHBI Pediatric Heart Network (UO1 HL068288, 2006-11): Single ventricle reconstruction-2 Trial

Researcher, Ontario Initiative in Personalized Stem Cell Medicine, Biorepository component

Achievements

• 2011 Editor, Cardiology Section, Pediatric Research
• 2010 Guest Editor, Review Series, Update in Pediatric Cardiovascular Pharmacology, Journal of Cardiovascular Pharmacology
• 2010 Chair, NHLBI Pediatric Heart Network Biospecimens Committee
• 2009-10 Chair, Peer Review Committee (Cardiac Biology/Regulation), American Heart Association
• 2008-11 Chair, Program Committee, Cardiovascular Disease in the Young, American Heart Association
• 2010 Program Chair, Section of Cardiology and Cardiac Surgery, American Academy of Pediatrics
• 2010 Program Chair and Organizer, Innovations in Heart Health: The Past, the Present, the Future (Biobank Family Education Day)
• 2011-13 Steering Committee Member, American Heart Association, Functional Genomics and Translational Biology Council (CVDY Liaison)
• 2010 Co-chair, Abstract Review Committee, American Transplant Congress
• 2009 Co-chair, American Heart Association International Congress 2009, on “Genetics/Genomics of Heart Disease”
• 2001-11 Steering Committee Member, NIH/NHLBI Pediatric Heart Network
• 2005-11 Executive Committee Member, Section of Cardiology and Cardiothoracic Surgery, American Academy of Pediatrics
• 2004-10 Editorial Board of Reviewers, Journal of Cardiovascular Pharmacology

Publications

Mital S, Chung W, Colan SD, Sleeper LA, Malhiot C, Arrington CB, Cnota JF, Graham EM, Mitchell MF, Goldmuntz E, Li JS, Levine JC, Lee TM, Margossian R, Hsu DT.  Renin-Angiotensin-Aldosterone Genotype Influences Ventricular Remodeling in Infants With Single Ventricle.  Circulation 2011 May 16

Hsu DT, Zak V, Mahony L, Sleeper LA, Atz A, Levine JC, Barker PC, Ravishankar C, McCrindle BW, Williams RV, Altmann K, Ghanayem NS, Margossian R, Chung WK, Border WL, Pearson GD, Stylianou MP, Mital S. Enalapril in Infants with Single Ventricle: Results of a multicenter randomized trial. Circulation 2010;122(4):333-40

Stevens K, Hakonarson H, Kim C, Doevendans P, Mital S, Raue J, Glessner J, Coles J G, Moreno V, Granger A, Gruber S B, Gruber P J. Common variation in ISL1 confers genetic susceptibility for human congenital heart disease. PlosOne 2010; May 26;5(5):e10855

Ohye RG, Sleeper LA, Mahony L, Newburger JW, Pearson GD, Lu M, Goldberg CS, Tabbutt S, Frommelt PC, Ghanayem NS, Laussen PC, Rhodes JF, Lewis AB, Mital S, Ravishankar C, Williams IA, Dunbar-Masterson C, Atz AM, Colan S, Minich LL, Pizarro C, Kanter KR, Jaggers J, Jacobs JP, Dent CK, Pike N, McCrindle BW, Virzi L, Gaynor JW, for the Pediatric Heart Network Investigators. Outcomes of the Norwood Procedure in Infants randomized to a modified Blalock-Taussig versus right ventricle-to-pulmonary artery shunt. N Engl J Med. 2010 May 27;362(21):1980-1992

Mital S. Translational Research: Clinicians and Basic Science. Amer Heart Journal 2011; Jan 161(1):21-27

Lai WW, Vetter VL, Richmond M, Li JS, Saul JP, Mital S, Colan SD, Newburger JW, Sleeper LA, McCrindle BW, Minich LL, Goldmuntz E, Marino BS, Williams IA, Pearson GD, Evans F, Scott JD, Cohen MS. Clinical research careers: reports from a NHLBI Pediatric Heart Network Clinical Research Skills Development Conference. Am Heart J. 2011 Jan; 161(1):13-67.

Davies R, Russo M, Hong K, Mital S, Mosca R, Quaegebeur J, Chen J. Increased Short- and Long-Term Mortality at Low-Volume Pediatric Heart Transplant Centers: Should Minimum Standards Be Set? Ann Thorac Surg 2010; Dec 22 [Epub ahead of print]

Ofori-Amanfo G, Hsu D, Lamour J, Mital S, O’Byrne M, Smerling A, Chen J, MOsca R, Addonizio L.  Heart transplantation in children with markedly elevated pulmonary vascular resistance: Impact of right ventricular failure on outcome.  J Heart Lung Transplant 2011; Jan 20 [Epub ahead of print]

Marelli A, Beauchesne L, Mital S, Therrien J, Silversides CK. Canadian Cardiovascular Society 2009 Consensus Conference on Management of Adults with Congenital Heart Disease: Introduction. Can J Cardiol 2010;26(3): e65-e69

Auerbach SA, Manlhiot C, Reddy S, Richmond ME, Gruber D, McCrindle BW, Deng L, Chen JM, Addonizio LJ, Chung WK, Mital S. Recipient Genotype is a Predictor of Outcomes after Pediatric Cardiac Transplantation. J Am Coll Cardiol 2009;53 1909-1917

Hsu DT, Mital S, Ravishankar C, Margossian R, Li JS, Sleeper LA, Williams RV, Levine JC, McCrindle BW, Atz AM, Serevedio D, Mahony L. Rationale and design of a trial of angiotensin converting enzyme inhibition in infants with single ventricle. American Heart Journal 2009 Jan; 157(1):37-45

Kaufman BD, Desai M, Osorio JC, Mosca RS, Chen JM, Ferrante AW, Mital S. Genomic profiling of left and right ventricular hypertrophy in congenital heart disease. J Card Failure 2008; 14(9):760-7

Osorio JC, Cheema FH, Martens TP, Mahmut N, Kinnear C, Duque AM, Bonney W, Homma S, Liao JK, Mital S. Simvastatin reverses cardiac hypertrophy caused by disruption of the bradykinin 2 receptor. Canadian J Physiol Pharmac 2008; 86(9): 633-42

Kaufman BD, Auerbach S, Reddy S, Manlhiot C, Deng L, Prakash A, Printz BF, Gruber D, Papavassiliou DP, Hsu DT, Sehnert AJ, Chung WK, Mital S. RAAS gene polymorphisms influence progression of pediatric hypertrophic cardiomyopathy. Hum Genet. 2007 Dec;122(5):515-23 Abstract

Gonzalez AM, Osorio JC, Manlhiot C, Gruber D, Homma S, Mital S. Hypertrophy signaling during peripartum cardiac remodeling. Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H3008-13 Abstract

Mital S. Value of surveillance biopsy in pediatric heart transplantation. Pediatric Transplantation 2007;11(3):233-5

Mital S. The right ventricle in congenital heart disease: is the right ventricle just a "weaker" left ventricle? Archives des Maladies du Coeur et des Vaisseaux Dec 2006; 99(12):1246-51

Reddy S, Osorio JC, Duque AM, Kaufman BD, Phillips AB, Chen JM, Quaegebeur J, Mosca RS, Mital S. Failure of right ventricular adaptation in children with tetralogy of fallot. Circulation 2006; 114: I-37-42 Abstract

Osorio JC, Reddy S, Cusmai G, Thaker H, Chen JM, Quaegebeur J, Mosca RS, Mital S. Vascular endothelial growth factor deficiency: a potential cause of left ventricular hypoplasia. Circulation 2006;114(18):II584, A2792

 Evans RW, Williams GE, Baron HM, Deng MC, Eisen HJ, Hunt SA, Khan MM, Kobashigawa JA, Marton EN, Mehra MR, Mital S. The economic implications of noninvasive molecular testing for cardiac allograft rejection. Amer J Transplantation 2005; 5: 1553-1558 Abstract

Mital S, Liao JK. Statins and the myocardium. Seminars in Vascular Medicine. 2005; 4 (4): 377-384

Reddy S, Matsuoka N, Gruber D, Kaufman BD, Masood T, Lamour JM, Chung WK, Mital S. Adrenergic receptor polymorphisms influence progression of dilated cardiomyopathy in children. Circulation 2005;112(17):II-515 (A2463)

Abraham SS, Osorio JC, Homma S, Wang JT, Thaker H, Liao JK, Mital S. Simvastatin preserves cardiac function in genetically determined cardiomyopathy. J Cardiovasc Pharmac 2004; 43 (3): 454-461 Abstract

Mital S, Loke KE, Chen JM, Mosca RS, Quaegebeur JM, Addonizio LJ, Hintze TH. Mitochondrial respiratory abnormalities in patients with end-stage congenital heart disease. J Heart Lung Transplant 2004; 23 (1): 72-79 Abstract

Kaufman BD, Deng L, Chung WK, Prakash A, Printz B, Gruber D, Lamour JM, Hsu DT, Addonizio LJ, Mital S. RAAS gene polymorphisms influence cardiac remodeling in children with hypertrophic cardiomyopathy. Circulation 2004; 110 (17) Suppl III; 2081