Brief Biography

Dr. Nathan joined the staff at The Hospital for Sick Children (SickKids) in 2004. He is a Clinician Investigator and the Director of the Aftercare program in the Division of Haematology/Oncology. 

Dr. Nathan received his medical degree from The University of Toronto in 1995. He then completed both a residency in paediatrics and a fellowship in paediatric haematology/oncology at SickKids. After completing a masters degree in Clinical Health Sciences (Health Research Methodology) at McMaster University in Hamilton, he spent a year in the Advanced Studies Program in Pediatric Oncology at the National Cancer Institute in Bethesda, Maryland.

Dr. Nathan’s clinical practice and research program is focused on survivors of childhood cancer. He is a member of the steering committees of the Children’s Oncology Group (COG) Survivorship and Outcomes Committee, the Childhood Cancer Survivor Study (CCSS), and the St. Jude Consortium for Pediatric Interventional Research. He is also a member of the Canadian Partnership Against Cancer’s (CPAC) National Survivor Working Group.

Clinical Care Activities

• Physician - Aftercare clinic in the Division of Haematology/Oncology
• Physician - Solid tumour section of the Division of Haematology/Oncology

Research Interests

• Long-term outcomes in survivors of childhood cancer, including cardiac, neurocognitive and metabolic late effects
• Health services utilization by adult survivors of childhood cancer

External Funding

• Canadian Institutes for Health Research (CIHR)
• Ontario Ministry of Research and Innovation
• Pediatric Oncology Group of Ontario (POGO)

Achievements

• 2010-2013 - Early Researcher Award (ERA), Ministry of Research and Innovation ($100,000)
• 2010 - Study on "Cancer screening in adult survivors of childhood cancer”, chosen as one of the “Major research advances in cancer treatment, prevention and screening” in 2009 by the American Society of Clinical Oncology (ASCO)
• 2008 - Study on "Risk based care in survivors of childhood cancer", chosen as one of the “Major research advances in cancer treatment, prevention and screening” in 2007 by the American Society of Clinical Oncology (ASCO)
• 2003 - American Society of Clinical Oncology Merit Award

Publications

Traubici J, Somers GR, Ling SC, Pearl RJ, Nathan PC: Pleuropulmonary blastoma in a child with autosomal-recessive polycystic kidney disease. Pediatric Radiology 2011 Jul 1 [Epub ahead of print].

Nathan PC, Schiffman JD, Huang S, Landier W, Bhatia S, Eshelman-Kent D, Wright J, Oeffinger KC, Hudson MM: Childhood Cancer Survivorship Educational Resources in North American Pediatric Hematology/Oncology Fellowship Training Programs: A Survey Study. Pediatric Blood & Cancer 2011 Jun 14. doi: 10.1002/pbc.23214 [Epub ahead of print].

Edelstein K, D'Agostino N, Bernstein LJ, Nathan PC, Greenberg ML, Hodgson DC, Millar BA, Laperriere N, Spiegler BJ: Long-term Neurcognitive Outcomes in Young Adult Survivors of Childhood Acute Lymphoblastic Leukemia. Journal of Pediatric Hematology/Oncology 2011 June 3 [Epub ahead of print].

French AE, Irwin MS, Navarro OM, Greenberg M, Nathan PC: Long-term hepatic outcomes in survivors of stage 4S and 4 neuroblastoma in infancy. Pediatric Blood & Cancer 2011 Mar 2. doi: 10.1002/pbc.23077 [Epub ahead of print].

Love E, Schneiderman JE, Stephens D, Lee S, Barron M, Tsangaris E, Urbach S, Staneland P, Greenberg M, Nathan PC: A cross-sectional study of overweight in pediatric survivors of acute lymphoblastic leukemia (ALL). Pediatric Blood & Cancer 2011 Feb 11. doi: 10.1002/pbc.23010 [Epub ahead of print].  

Abosoudah I, Greenberg ML, Ness KK, Benson L, Nathan PC: Echocardiographic surveillance for asymptomatic late-onset anthracycline cardiomyopathy in childhood cancer survivors. Pediatric Blood & Cancer 2011: 57 (3): pp 467-472.  

Krull KR, Annett RD, Pan Z, Ness KK, Nathan PC, Srivastava DK, Stovall M, Robison LL, Hudson MM: Neurocognitive functioning and health-related behaviors in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. European Journal of Cancer 2011: 47 (9): pp 1380-1388.

Nathan PC, Hayes-Lattin B, Sisler JJ, Hudson MM: Critical Issues in Transition and Survivorship for Adolescents and Young Adults with Cancers. Cancer 2011: 117 (10sup): pp 2335-2341.

Lee Chong A, Gupta A, Punnett A, Nathan PC: A Cross Canada Survey of Sperm Banking Practices in Pediatric Oncology Centers. Pediatric Blood & Cancer 2010: 55 (7): pp 1356-1361.

Nathan PC, Ness KK, Mahoney MC, Li Z, Hudson MM, Ford JS, Landier W, Stovall M, Armstrong GT, Hendeson TO, Robison LL, Oeffinger KC: Screening and surveillance for second malignant neoplasms in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study (CCSS). Annals of Internal Medicine 2010: 153 (7): pp 442-451.

Oeffinger KC, Nathan PC, Kremer LCM: Challenges after Curative Treatment for Childhood Cancer and Long-Term Follow Up of Survivors. Hematology/Oncology Clinics of North America 2010: 24 (1): pp 129-149.

Dupuis LL, Nathan PC: Optimizing emetic control in children receiving antineoplastic therapy: Beyond the guidelines. Pediatric Drugs 2010: 12 (1): pp 51-61.

Goldsby RE, Lui Q, Nathan PC, Bowers DC, Yeaton-Massey A, Raber SH, Hill D, Armstrong GT, Yasui Y, Zeltzer L, Robison LL & Packer RJ: Late occurring neurologic sequelae in adult survivors of childhood acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study. Journal of Clinical Oncology 2010: 28 (2): pp 324-331.

Nathan PC, Wasilewski-Masker K, Janzen LA: Long-term outcomes in survivors of childhood acute lymphoblastic leukemia. Hematology/Oncology Clinics of North America 2009: 23 (5): pp 1065-1082.

Laverdiere C, Liu Q, Yasui Y, Nathan PC, Gurney JG, Stovall M, Diller LR, Cheung N, Wolden S , Robison LL, Sklar CA: Long-term outcomes in survivors of neuroblastoma: a report from the Childhood Cancer Survivor Study. Journal of the National Cancer Institute 2009: 101 (16): pp 1131-1140.

Ristovski-Slijepcevic S, Barr R, Bernstein M, Nathan PC: A cross-Canada survey of clinical programs for the care of survivors of cancer in childhood and adolescence. Paediatrics & Child Health 2009: 14 (6): pp 375-378.

Nathan PC, Ford JS, Henderson TO, Hudson MM, Emmons KM, Casillas JN, Lown EA, Ness KK, Oeffinger KC: Health Behaviors, Medical Care, and Interventions to Promote Healthy Living in the Childhood Cancer Survivor Study Cohort. Journal of Clinical Oncology 2009: 27 (14): pp 2363-2373.

Gurney JG, Krull KR, Kadan-Lottick N, Nicholson HS, Nathan PC, Zebrack B, Tersak JM & Ness KK: Social Outcomes in the Childhood Cancer Survivor Study Cohort. Journal of Clinical Oncology 2009: 27 (14): pp 2390-2395.

Nathan PC, Greenberg ML, Ness KK, Hudson MH, Mertens AC, Mahoney MC, Gurney JG, Donaldson SS, Leisenring WM, Robison LL, Oeffinger KC: Medical Care in Long-Term Survivors of Childhood Cancer: A Report from the Childhood Cancer Survivor Study (CCSS). Journal of Clinical Oncology 2008: 26 (27): pp 4401-4409.

Oeffinger KC, Nathan PC, Kremer LCM: Challenges after Curative Treatment for Childhood Cancer and Long-Term Follow Up of Survivors. Pediatric Clinics of North America 2008: 55 (1): pp 251-273.

Tabori U, Revach G, Nathan PC, Strahm B, Rachlis A, Shago M, Grant R, Doyle J, Malkin D: Toxicity and outcome of children with treatment related acute myeloid leukemia. Pediatric Blood & Cancer 2008: 50 (1): pp 17-23.

Nathan PC, Ness KK, Greenberg ML, Whitton J, Hudson M, Mertens A, Laverdiere C, Wolden S, Davidoff A, Robison LL, Zeltzer L, Gurney J: Quality of life in survivors of childhood Wilms' tumor or neuroblastoma: A report from the Childhood Cancer Survivor Study. Pediatric Blood & Cancer 2007: 49 (5): pp 704-715.

Nathan PC, Patel S, Dilley K, Goldsby R, Harvey Jeanne, Jacobsen C, Kadan-Lottick N, McKinley K, Millham AK, Moore I, Okcu MF, Woodman CL, Brouwers P, Armstrong FD: Guidelines for Identification of, Advocacy for, and Intervention in Neurocognitive Problems in Survivors of Childhood Cancer. Archives of Pediatrics and Adolescent Medicine 2007: 161 (8): pp 798-806.

Mansky P, Arai A, Stratton P, Bernstein D, Long L, Reynolds J, Chen D, Steinberg SM, Lavende N, Hoffman K, Nathan PC, Parks R, Augustine E, Chaudhry, Derdak J, Wiener L, Gerber L, Mackall C: Treatment Late Effects in Long-term Survivors of Pediatric Sarcoma. Pediatric Blood & Cancer 2007: 48 (2): pp 192-199.

Chow LML, Nathan PC, Hodgson DC, Jenkin D, Weitzman S, Grant RM, Manson D, Bross A, Doyle JJ, Danjoux C, Greenberg M: Survival and late effects in children with Hodgkin's lymphoma treated with MOPP/ABV and low-dose extended-field irradiation. Journal of Clinical Oncology 2006: 24 (36): pp 5735-5741.

Nathan PC, Whitcomb T, Wolters PL, Steinberg SM, Balis FM, Brouwers P, Hunsberger S, Bleyer WA, Feusner J, Sather H, Miser J, Odom LF, Poplack D, Reaman G: Very high-dose methotrexate (33.6g/m2)) as CNS preventive therapy for childhood acute lymphoblastic leukemia: Results of National Cancer Institute/Children's Cancer Group trials CCG-191P, CCG-134P and CCG-144P. Leukemia & Lymphoma 2006: 47 (12): pp 2488-2504.

Nathan PC, Jovcevska V, Ness KK, D'Agostino NM, Staneland P, Urbach SL, Barron M, Barrera M & Greenberg ML: The Prevalence of Overweight and Obesity in Pediatric Survivors of Cancer. Journal of Pediatrics 2006: 149 (4): pp 518-525.

Nathan PC, Tomlinson G, Dupuis LL, Greenberg ML, Ota S, Bartels U, Feldman BM: A pilot study of ondansetron plus metopimazine versus ondansetron monotherapy in children receiving highly-emetogenic chemotherapy: A Bayesian randomized serial N-of-1 trials design. Supportive Care in Cancer 2006: 14 (3): pp 268-276.

Spiegler B, Kennedy K, Maze R, Greenberg ML, Weitzman S, Hitzler JK, Nathan PC: Comparison of long-term neurocognitive outcomes in young children with ALL treated with cranial radiation or high-dose or very high-dose intravenous methotrexate. Journal of Clinical Oncology 2006: 24 (24): pp 3858-3864.

Nathan PC, Furlong W, Barr RD: Challenges to the measurement of health-related quality of life in children receiving cancer therapy. Pediatric Blood & Cancer 2004: 43 (3): pp 215-223.