Publications
Selected Lymphocyte Development Publications
Visan I, Tan JB, Yuan JS, Harper JA, Koch U, Guidos CJ (2006) Regulation of T lymphopoiesis by Notch1 and Lunatic fringe-mediated competition for intrathymic niches. Nat Immunol. 7(6):634-43
Visan I, Yuan JS, Tan JB, Cretegny K, Guidos CJ (2006) Regulation of intrathymc T cell development by Lunatic Fringe-Notch1 interactions. Immunol Rev. 209:76-94
Tan JB, Visan I, Yuan JS, Guidos CJ (2005) Requirement for Notch 1 signals at sequential early stages of intrathymic Tcell development. Nat Immunol. 6(7):671-9
Koch U, Yuan JS, Harper JA, Guidos CJ (2003) Fine-tuning Notch1 activation by endocytosis and glycosylation. Semin Immunol. 15(2):99-106 French MB, Koch U, Shaye RE, McGill MA, Dho SE, Guidos CJ, McGlade CJ (2002) Transgenic expression of Numb inhibits Notch signaling in immature thymocytes but does not alter T cell fate specification. J Immunol 168(7):3173-80
Koch U, Lacombe TA, Holland D, Bowman JL, Cohen BL, Egan SE, Guidos CJ (2001) Subversion of the T/B lineage decision in the thymus by Lunatic Fringe-mediated inhibition of Notch-1. Immunity 15(2):225-36 Groves T, Smiley P, Cook MP, Forbush K, Prlmutter RM, Guidos CJ (1996) Fyn can partially substitute for Lck in T lymphocyte development. Immunity. 5(5):417-28
Fischer KD, Zmuldzinas A, Gardner S, Barbacid M, Bernstein A, Guidos C (1995) Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes. Nature. 374(6521):474-7.
Selected Lymphoblastic Leukemia Publications
Matei IR, Gladdy RA, Nutter L, Guidos CJ, Danska JS (2007) ATM disrupts TCR-alpha locus integrity and the maturation of CD4+CD8+ thymocytes. Blood. 109(5):1887-96
Guidos C (2006) Thymus and T-lymphocyte development: what is new in the 21st century? Immunol Rev. 209:5-9
Matei IR, Guidos CJ, Danska JS (2006) ATM-dependent DNA damage surveillance in T-cell development and leukemogenensis: the DSB connection. Immunol Rev. 209:142-58
Gladdy RA, Taylor MD, Williams CJ, Grandal I, Karaskova J, Squire JA, Rutka JT, Guidos CJ, Danska JS. (2003) The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice. Cancer Cell. 3(1):37-50
Williams CJ, Grandal I, Vesprini DJ, Wojtyra U, Danska JS, Guidos CJ. (2001) Irradiation promotes V(D)J joining and RAG-dependent neoplastic transformation in SCID T-cell precursors. Mol Cell Biol. 21(2):400-13 Danska JS, Holland DP, Mariathasan S, Williams KM, Guidos CJ. (1996) Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes. Mol Cell Biol. 16(10):5507-17 Guidos CJ, Williams CJ, Grandal I, Knowles G, Huang MT, Danska JS. (1996) V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors. Genes Dev. 10(16):2038-54
Danska JS, Pflumio F, Williams CJ, Huner O, Dick JE, Guidos CJ. (1994) Rescue of T cell-specific V(D)J recombination in SCID mice by DNA-damaging agents. Science. 266(5184):450-5
New papers
Matei IR, Gladdy RA, Nutter L, Guidos CJ, Danska JS (2007)ATM deficiency disrupts Tcra locus integrity and the maturation of CD4+CD8+ thymocytes. Blood. 109(5):1887-96.
Gladdy RA, Nutter LM, Kunath T, Danska JS, Guidos CJ (2006) p53-independent apoptois disrupts early organogenesis in embryos lacking both ataxa-telangiectasia mutated and Prkdc. Mol Cancer Res. 4(5): 311-8.
Matei IR, Guidos CJ, Danska JS (2006) ATM-dependent DNA damage surveillance in T-cell development and leukemogenesis: the DSB connection. Immunol Rev. 209:142-58.
Gladdy RA, Taylor MD, Williams CJ, Grandal I, Karaskova J, Squire JA, Rutka JT, Guidos CJ, Danska JS. (2003) p53-independent apoptois disrupts early organogenesis in embryos lacking both ataxa-telangiectasia mutated and Prkdc The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice. Cancer Cell. 3(1):37-50.