Publications
The following are some recent and key publications from the Rosenblum Lab:
Gill PS, Rosenblum ND. Control of murine kidney development by Sonic Hedgehog and its GLI effectors. Cell Cycle 5:13, 1426-1430, 2006.
Hu MC, Mo R, Bhella S, Wilson CW, Chuang P-T, Hui C-C, Rosenblum ND. GLI3-dependent transcriptional repression of Gli1 and Gli2 and kidney patterning genes disrupts renal morphogenesis. Development 133:569-578, 2006.
Hartwig S, Hu MC, Cella C, Piscione TD, Filmus J, Rosenblum ND. Glypican-3 Modulates Inhibitory Bmp2-Smad Signaling to Control Renal Development in vivo. Mechanisms of Development 122: 928-938, 2005.
Leung-Hagestejn C, Hu MC, Mahendra AS, Hartwig S, Klamut H, Rosenblum ND, Hannigan GE. Integrin linked kinase mediates BMP7 dependent renal epithelial cell morphogenesis. Molecular and Cellular Biology 25: 3648-3657, 2005.
Hu MC, Rosenblum ND. Smad 1, beta-catenin and TCF4 associate in a molecular complex with the c-MYC promoter in dysplastic renal tissue and cooperate to control c-MYC transcription. Development. 132:215-225, 2005
Hu MC, Hartwig S, Wasserman D, Rosenblum ND. P38MAPK Acts in the BMP7-dependent stimulatory pathway during epithelial cell morphogenesis and is regulated by Smad1. Journal of Biological Chemistry 279: 12051-12059, 2004
Hu MC, Rosenblum ND. Genetic regulation of branching morphogenesis: lessons learned from loss-of-function phenotypes. Pediatric Research 54: 433-438, 2003.
Hu MC, Piscione TD, Rosenblum ND. Elevated Smad 1/beta-catenin molecular complexes and renal medullary dysplasia in ALK3 transgenic mice. Development 130: 2753-2766, 2003.
Goldman M, Smith A, Shuman C, Caluseiu O, Wei CH, Steele L, Ray P, Sadowski P, Squire J, Weksberg R, Rosenblum ND. Renal abnormalities in Beckwith-Wiedemann Syndrome are associated with 11p.15.5 uniparental disomy. J Am Soc Neph 13:2077-2084, 2002.
Piscione TD, Rosenblum ND. Molecular control of renal branching morphogenesis: current knowledge and emerging insights. Differentiation 70: 227-246, 2002.
Grisaru S, Cano-Gauci D, Tee J, Filmus J, Rosenblum ND. Glypican-3 modulates BMP and FGF mediated effects during renal branching morphogenesis. Developmental Biology 231: 31-46, 2001.
Piscione TD, Phan T, Rosenblum ND. BMP7 controls renal collecting system cell proliferation and apoptosis via Smad1-dependent and -independent pathways. Am J. Physiology Renal Physiology 280: F19-F33, 2001.
Gupta IR, Macias-Silva M, Kim S, Zhou X, Piscione TD, Whiteside C, Wrana JL, Rosenblum ND. BMP2/ALK3 and HGF signal in parallel to regulate collecting duct morphogenesis. J Cell Science 113:269-278, 2000.
Gupta IR, Piscione TD, Grisaru S, Phan T, Macias-Silva M, Zhou X, Whiteside C, Wrana JL, Rosenblum ND. Protein kinase A is a negative regulator of renal branching morphogenesis and modulates inhibitory and stimulatory bone morphogenetic proteins. J Biol Chem, 274: 26305-26314, 1999.
Senior Responsible Author Piscione TD, Yager TD, Gupta IR, Grinfeld B, Pei Y, Attisano L, Wrana JL, Rosenblum ND. Bone morphogenetic protein -2 and osteogenic protein -1 exert direct and opposite effects on renal branching morphogenesis. Am J Physiol. 273: F961-F975, 1997.
A full listing of Dr. Rosenblum's publications can be found at PubMed, available via the National Centre for Biotechnology Information (NCBI) Entrez retrieval system. Please click on the link below to be directed to that site. Click Here for Publications